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AMPK (Adenosine 5′-monophosphate (AMP)-activated protein kinase), as an important kinase regulating energy homeostasis, is one of the central regulators of eukaryotic cell and organism metabolism. It is responsible for regulating cellular capacity input and output and maintaining the smooth functioning of cellular physiological activities. AMPK is also a key protein involved in various signaling pathways.  …

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What is Phosphatidylglycerol? Phosphatidylglycerol (PG) is a type of phospholipid, a class of molecules that are crucial components of biological membranes. These membranes are found in cells and organelles, and they serve as barriers that separate the interior of these structures from the external environment.   What are The Sources of Phosphatidylglycerol? Phosphatidylglycerol (PG) is…

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Introduction of Drug Affinity Responsive Target Stability (DARTS) Drug target protein identification is an important step in the research and development of new drugs. Drug Affinity Response Target Stability (DARTS) is a technique that can rapidly and directly identify potential target proteins of small molecule drugs. That is, it prevents the target protein from being hydrolyzed by…

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What is CAR T-cell therapy? Car-t cell therapy involves genetically engineering T cells isolated from patients or allogeneic donors to express chimeric antigen receptors (CAR) that specifically recognize and kill tumor cells.   As a “living” drug, CAR-T therapy is very different from traditional drugs. It is a new type of precision targeted therapy for…

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Most biological agents enter the body directly without passing through the gastrointestinal tract, so in addition to biological activity, relevant authorities have very strict requirements on impurities in drugs. Among them, the host cells residual DNA has always been the focus of regulatory agencies because of its special potential safety risks.   Although recombinant protein drugs, antibody…

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